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Psoriatic Arthritis Therapeutics Market Overview and Regional Outlook Study

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Transparency Market Research (TMR) has published a new report titled, “Psoriatic Arthritis Therapeutics Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018–2026”. According to the report, the global psoriatic arthritis therapeutics market was valued at US$ 6,011.7 Mn in 2017. It is projected to expand at a CAGR of 11.4% from 2018 to 2026. High prevalence of psoriatic arthritis, large unmet medical needs, and new product approvals are anticipated to drive the global market in the next few years. North America is expected to dominate the global psoriatic arthritis therapeutics market during the forecast period, followed by Europe.

Potential unmet medical needs for moderate to severe psoriatic arthritis, increase in adoption of biologic drugs, and approvals of new therapeutic drug classes in the U.S. and Europe are likely to drive the psoriatic arthritis therapeutics market in these regions during the forecast period. The market in Asia Pacific is projected to expand at a high CAGR during the forecast period.

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High prevalence and increase in incidence rate of psoriatic arthritis to drive market

High prevalence and rise in incidence rate of psoriatic arthritis across the globe is a key factor driving the global psoriatic arthritis therapeutics market. Chances of developing psoriatic arthritis among patients with psoriasis is high, and the number of patients with psoriatic arthritis has been increasing significantly in the last few years. According to the International Federation of Psoriasis Association, more than 125 million people were affected with psoriasis, globally, in 2015. It is estimated that between 10% and 30% of patients with psoriasis tend to develop psoriatic arthritis. According to the study published in the Journal of the American Academy of Dermatology, in 2013, Denmark had the highest prevalence rate of psoriatic arthritis, with around 42% prevalence rate, while the lowest prevalence rates were recorded in Canada and Belgium. Thus, the high prevalence and substantial rise in incidence rate of psoriasis and psoriasis-led psoriatic arthritis across globe is a key factor driving the global psoriatic arthritis therapeutics market.

Interleukin inhibitors and PDE4 inhibitors drugs to propel the psoriatic arthritis therapeutics market

The report offers a detailed segmentation of the global psoriatic arthritis therapeutics market based on different therapeutic drug classes approved and commercialized for psoriatic arthritis. Based on drug class, the global market has been segmented into TNF inhibitors, interleukin inhibitors, PDE4 inhibitors, and others. Interleukin inhibitors drugs have evolved as new therapeutic drug class for the treatment of psoriatic arthritis when other therapeutic drugs classes, especially TNF alpha inhibitors, fail to relieve the symptoms of psoriatic arthritis. Interleukin inhibitor drugs, especially IL-17A inhibitor drugs, have shown the highest clinical efficacy, as compared to any other biologic drug available, to relive the symptoms of psoriatic arthritis. Interleukin inhibitors have been recently approved for the treatment of psoriatic arthritis and are increasingly gaining popularity among physicians across the globe.

Currently, only four interleukin inhibitors ? Cosentyx (Secukinumab), Stelara (USTEKINUMAB), Tremfya (Guselkumab) and Taltz (Ixekizumab) ? have been approved for the treatment of psoriatic arthritis. Interleukin inhibitors drug sales are estimated to rise about four times by the end of 2026. PDE4 inhibitor is the new therapeutic drug that was approved by the USFDA, in March 2014, for the treatment of psoriatic arthritis. Currently, Otezla (Apremilast) is the only approved PDE4 inhibitor drug for psoriatic arthritis treatment. Within one year of launch, Otezla generated a sale of more than US$ 1 Billion in the year 2016.

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Parenteral route of administration to dominate global market

In terms of route of administration, the global psoriatic arthritis therapeutics market has been segmented into oral route, parenteral route, and topical routes. The parenteral route segment dominated the global market in 2017. It is likely to maintain its dominance by the end of 2026. Majority of the therapeutic drugs available for the treatment of moderate to severe psoriatic arthritis are biologics drugs that are administered through the subcutaneous and intravenous routes. The high cost and large volume prescription of biologic drugs contributed to the leading share held by the parenteral route segment in 2017.

Hospital pharmacies segment to account for high market share

In terms of distribution channel, the global psoriatic arthritis therapeutics market has been segregated into hospital pharmacies, retail pharmacies, and online pharmacies. The hospital pharmacies segment is projected to account for a significant share of the market by 2026. Rise in the number of hospital admissions of patients with psoriatic arthritis and high cost of treatment are anticipated to contribute to the high share of the segment by the end of 2026. Promising biologic product pipeline of leading biopharmaceutical companies is likely to receive approval and commercialization in the near future. Biologic drugs are most commonly and easily available at hospital pharmacy stores. Hence, expected launch and commercialization of biologic therapeutic drugs is likely to drive the hospital pharmacies segment during the forecast period.

Asia Pacific offers high incremental opportunity

The psoriatic arthritis therapeutics market in Asia Pacific is projected to expand at a high CAGR during the forecast period. High prevalence of psoriatic arthritis in highly populated countries, such as China and India, rapidly improvement in health care infrastructure, increase in access to health care facilities, and rise in per capita health care expenditure in the region are likely to fuel the market in Asia Pacific during the forecast period. Large base of pharmaceutical companies in countries such as India, Japan, and China also drives the market in the region. High demand and increased adoption of biologic drugs in developed markets, such as Australia & New Zealand, are projected to propel the psoriatic arthritis therapeutics market in Asia Pacific. For instance, in Australia, the number of patients with severe psoriasis receiving treatment under the Pharmaceutical Benefit Scheme (PBS) with biologics has increased by more than 60% between 2014 and 2016.

Key trend of M&A among leading players to diversify and strengthen psoriatic arthritis product portfolio

The global psoriatic arthritis therapeutics market is highly consolidated, with a few global players accounting for a major share in respective regions. Leading players in psoriatic arthritis therapeutics are engaged in mergers, acquisitions, and strategic collaborations to broaden their psoriatic arthritis therapeutics portfolio. For instance, more than 20 mergers, acquisitions, and strategic collaborations have taken place between 2014 and 2018. Most biopharmaceutical companies have invested significantly in clinical R&D for the development of psoriatic arthritis therapeutics products. Key players operating in the psoriatic arthritis therapeutics market include AbbVie, Inc., Janssen Biotech, Inc., Novartis AG, Amgen, Inc., Celgene Corporation, Pfizer, Inc., Eli Lilly and Company, UCB, Inc., Biogen Inc., and Bristol-Myers and Squibb Company.

posted Feb 12 by Rohini Chaudhari

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Bone Holding Forceps and Cutters Market: Vital Tools in Surgery and Repair of Bones

Bone holding forceps are handheld, hinged instruments used for grasping and holding bones. These forceps are commonly used to stabilize bones during repair.
These holding forceps could also be used to remove bone fragments from a surgical site. These are available in a number of sizes, as well as with or without ratchets, making these versatile instruments that can be used on both small and large bones.

Bone cutting forceps or cutters are instruments used for cutting in orthopedic surgeries. These are instruments that have two blades and a handle to compress or hold tissues in orthopedic instrument surgical operations.

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These instruments are required for clean and sterile surgery environment. These forceps have a double-action function; these are used to grip tissues and have blades for cutting.

Key Drivers and Restraints of Global Bone Holding Forceps and Cutters Market

Increase in the number of orthopedic and dental surgeries is the major factor boosting the growth of the global bone holding forceps and cutters market
According to the International Osteoporosis Foundation, osteoporosis causes more than 8.9 million fractures across the world each year

Rise in the number of road accidents and increase in the geriatric population prone to bone disorders drive demand for bone holding forceps and cutter across the globe

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Availability of forceps in different sizes and dimensions fuels demand for these surgical tools

High Cost of Surgical Procedures to Hamper Global Market

High cost of certain orthopedic surgical procedures hampers the growth of the global bone holding forceps and cutters market

Moreover, unskilled personnel for performing orthopedic procedures could cause complications during surgery and injuries. This factor is projected to restrain the global bone holding forceps and cutters market. 

Disposable to be Highly Lucrative Segment

Based on product type, the global bone holding forceps and cutters market can be bifurcated disposable and reusable

The reusable segment dominated the global market in 2018 owing to application during surgeries and availability of sterilized instruments after each procedure
The disposable segment is projected to be more lucrative in the next few years due to less chance of infection and low cost

Stainless Steel to Dominate Global Market

In terms of material, the global bone holding forceps and cutters market can be classified into stainless steel, tungsten, and others

The stainless steel segment dominated the global bone holding forceps and cutters market in 2018. Ability to withstand repeated sterilization in high temperature autoclaves, rust free, and durability of edges are the key features that propel the segment.

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Hospitals to be Promising Segment

Based on end-user, the global bone holding forceps and cutters market can be divided into hospitals, ambulatory surgery centers, and others
The hospitals segment dominated the global market in 2018 and the trend is projected to continue during the forecast period

Hospitals is anticipated to be a highly lucrative segment during the forecast period owing to higher number of surgical procedures performed in these settings and availability of various surgical tools

North America to Lead Global Market

In terms of region, the global bone holding forceps and cutters market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa

North America dominated the global bone holding forceps and cutters market in 2018 owing to higher number of surgical procedures, increase in adventure activities & road accidents which lead to surgeries, and presence of major players in the region

According to the Agency for Healthcare Research and Quality (AHRQ), in the U.S., the number of orthopedic surgical procedures increased from 2,740,000 in 2001 to 3,785,000 in 2011, an increase of 38% in 10 years

The bone holding forceps and cutters market in Asia Pacific is projected to expand at a higher CAGR during the forecast period. Increase in the geriatric population prone to orthopedic problems, rise in the number of orthopedic surgeries, and growing medical tourism are the major drivers of the bone holding forceps and cutters market in the region.

Key Manufacturers Operating in Global Bone Holding Forceps and Cutters Market

Leading players in the global Bone Holding Forceps and Cutters market are:

B. Braun Melsungen AG
Stryker Corporation
Integra LifeSciences Corporation
CONMED Corporation
Medline Industries, Inc.
Zimmer Biomet Holdings, Inc.
Sklar Surgical Instruments
Arthrex, Inc.
Millennium Surgical Corp.
Azort

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Single-use bioreactors, which are ideally suited for manufacturing biopharmaceutical products because of their high-performance, have become highly evolved these days thanks to constant efforts by players to develop products. They are seen working on improving designs, sensor systems, film technology, and stirring mechanism of single-use bioreactors. In doing so, they are factoring in the specific requirements of their clients vis-à-vis gene and cell therapies and for continued bioprocessing.

Some of the prominent participants in the global single-use bioreactors market are Stedim Biotech, Sartorius Merck Millipore, Thermo Fisher Scientific, GE Healthcare, Celltainer Biotech, Danaher, Applikon Biotechnology, Parker Hannifin, Cesco Bioengineering, PBS Biotech, Cellexus, Distek, Pierre Guerin, Eppendorf, and Solida Biotech.

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Transparency Market Research (TMR), which recently prepared a report on the global market for single-use bioreactors, finds that it is primed for good growth over the course of the forecast period between 2017 and 2026. It states that by registering a CAGR of 13.5%, the market will likely reach a value of US$1.55 bn by the end of 2026.

The different types of single-use bioreactors available in the market are media bags, filtration assemblies, and single use bioreactor systems. The single use bioreactor systems of them are expected to expand at a healthy clip in the next couple of years. Media bags form another attractive product segment and together with single use bioreactor systems, is expected to generate over half the revenue in the market.

North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa are some of the prominent regions in the global market for single-use bioreactors. Europe, of them, leads the market because of the presence of some of the well-known pharmaceutical companies in the region. Supportive policies meant to boost efforts by biopharmaceutical companies to come up with new therapies in biologics is also benefitting the market in the region along with the rising application of single-use bioreactors in cell culture-based manufacturing.

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Manufacturers Focus on Fixing Product Issues to Generate New Growth Avenues

Commercial considerations are mostly driving the use of single-use bioreactors. Manufacturers are keen to ensure that their products bring about cost savings in biopharmaceutical companies. “While single-use bioreactor bags are generating pathways that can manufacture protein-based drugs securely, the compounds or materials have a tendency to leak on account of the extrusion process that makes the bag films thin. Fixing of such risks by stabilizing the materials has spelt new opportunities for savvy companies trying to increase their sales,” explains the TMR analyst who prepared the report.

Biopharmaceutical Firms at the Forefront of Driving Demand

Depending upon end user, the biopharmaceutical companies are predicted to generate maximum demand. Currently, players are focusing on designing new generation single-use bioreactors, keeping in mind the final drug product required by end users.

Recent developments in single-use bioreactors by manufacturers are focused on improving mixing, bringing down complexity, and avoiding leakage, and other integrity issues. Apart from that, bettering cell-culture processes are also driving rising adoption of single-use bioreactors.

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The North America porcine vaccine market is  highly fragmented owing to the presence of numerous large and small players. Zoetis, Inc., Merial Animal Health, Merck Animal Health, and Elanco Animal Health are the top four players that accounted for around 74.0% of entire market in 2015. Some of the other key palyers in the market are Bimeda Animal Health, Bayer AG., Boehringer Ingelheim GmbH, Vetoquinol, and Ceva Santé Animale. All these players are working on building diverse product portfolios, indulging in mergers and acquisitions, and investing in research and development activities in order to launch new and more effective vaccination for porcine. For example, Boehringer Ingelheim GmbH launched two new porcine vaccines ReproCyc and Ingelvac.

According to Transparency Market Research, the North America porcine vaccine market is likely to witness growth at a CAGR of 5.3% within the forecast period from 2016 to 2024. In 2015, the market was valued at US$540.9 mn, which is expected to reach around worth US$926.2 mn by the end of 2024. Geographically, the market is dominated by the U.S. It had a share of 63.0% in 2015. The market is anticipated to grow with a CAGR of 6.6% in coming years. Moreover, in terms of technology used, live attenuated vaccines are foreseen to exhibit growth with a robust CAGR of 5.9% within the forecast period.

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Rise in prevalence of Swine Diseases to Propel Market growth in Coming Years

The market for porcine vaccines in North America is predominantly driven by the rise in prevalence of swine illness and the constantly growing demand for meat and gelatin in the market. Due to globalization and rapid change in atmosphere, the rate of outbreak of various ailments in animals are on the rise. These diseases are transmissible to humans. Since, pigs are an exceptionally popular source of red meat, consumed in high volumes around the world, the market for porcine vaccine is expected to be boosted in the near future. Zoonotic infections in this class of domesticated animals can be exceedingly wrecking for humans as well.

High Maintenance and Storage Expense to Hamper Market Growth in Future

Proper handling and storage of vaccines holds an important role in achieving high success rate against any vaccine-preventable illness. It is of absolute necessity to strictly comply with proper storage and handling process. Otherwise it causes loss of several dollars in revaccination and waste vaccine, requires keeping up proper cold chains. Such cold chains are required in all nodes of the supply network, beginning from the makers to the healthcare providers. The high expenses of maintaining and handling storage conditions is one of the major drawbacks experienced by the North America porcine vaccine market. This factor is anticipated to hamper the market's development to some degree within the forecast period.

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Key Takeaways:

  • The market for porcine vaccines in North America is predominantly driven because of the rise in prevalence of swine illness and the constantly growing demand for meat and gelatin in the market.
  • North America being third largest consumer of pork, becomes a key to rising focus on health and wellness of swine from livestock, driving porcine vaccine market.

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Fetal Monitoring Systems Market: Introduction

Transparency Market Research has published a new report titled “Fetal Monitoring Systems Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2019–2027”. According to the report, the global fetal monitoring systems market was valued at approximately US$ 2.8 Bn in 2018. It is expected to expand at a CAGR of ~3% during the forecast period from 2019 to 2027. Monitoring procedures are the basis to evaluate the clinical state of patients and to access changes in their conditions, thus providing necessary interventions in time.

Traditional fetal monitoring systems received a fundamental improvement by new technological devices allowing longer and deeper data collection of fetus and mother. Expansion of the global fetal monitoring systems market can be attributed to rise in prevalence rate of birth asphyxia, fat gain during pregnancy, and number of preterm births worldwide. North America is a highly lucrative market for fetal monitoring systems due to mandatory fetal monitoring of pregnant women and rise in number of users of home-based fetal monitoring systems.

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Rise in Awareness among Pregnant Women with High Body Mass Index to Drive Fetal Monitoring Systems Market

According to the data from the Public Library of Science, the percentage of overweight women during pregnancy increased from 29.8% in 1980 to 38.0% in 2013 globally. Prevalence of excessive gestational weight gain and obesity during all trimesters is a major cause of concern for fetus health. Moreover, doctors advise regular monitoring of fetus and the mother till successful delivery. This, in turn, is driving the market.

Development of Portable Fetal Monitoring Systems to Drive Global Market

Based on product, the global fetal monitoring systems market has been divided into systems and accessories. The systems segment dominated the global fetal monitoring systems market in 2018. Expansion of the segment can be attributed to development of portable fetal monitoring systems for home use and rise in number of hospitals.

Hospitals & Nursing Homes to be key End Users

Based on end user, the global fetal monitoring systems market has been classified into hospitals & nursing homes, clinics, and home settings. Hospitals & nursing home is projected to be a highly lucrative segment from 2019 to 2027 and hold major share in terms of end-user. However, the home settings segment is anticipated to expand at a high CAGR during the forecast period. Rise in awareness about the advantages of fetal monitoring such as low cost of expenses from hospitals and development of convenient fetal monitoring systems for home use are some factors due to which home settings is expected to grow at faster rate.

North America to Dominate Fetal Monitoring Systems Market

In terms of region, the global fetal monitoring systems market has been divided into five major regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominated the global fetal monitoring systems market in 2018. Favorable reimbursement facilities, high awareness among patients for fetal monitoring, quick adoption of advanced technology fetal monitoring systems, and presence of major players who constantly promote their brands through wide distribution channels are key factors driving the market in the region. Asia Pacific is a lucrative market for fetal monitoring systems, due to large number of preterm birth rate in the region, rise in awareness about the advantages of home monitoring, and rise in disposable income in countries in the region, such as India.

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Competition Landscape

Abbott, F. Hoffmann-La Roche Ltd, and Siemens Healthineers AG are a few leading players operating in the fetal monitoring systems market. The global fetal monitoring systems market is fragmented in terms of number of players. Key players in the global market include Koninklijke Philips N.V., GE Healthcare, Mindchild Medical, Inc., Nemo Healthcare, Huntleigh Healthcare Limited (Arjo), Edan Instrument Inc., Neoventa Medical AB, Clinical Innovations, LLC., and SUNRAY MEDICAL APPARATUS CO.,LTD. New product approvals for specific indication, widespread distribution channels, and higher R&D investment are key strategies adopted by major players operating in the market.

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Auto Keratometer Market: Introduction

  • Keratometry is the concept of measuring anterior surface of cornea curvature across a fixed chord length. Keratometer, also known as opthalmometer, is the instrument used to measure the curvature. Auto keratometer is a type of keratometer based on the principle of constant image size and variable image size. Auto keratometer is a compact device and comparatively easier to operate. This keratometer allows reflecting corneal image on an electronic photosensitive device which then records size and radius of the curvature.

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  • Auto Keratometer (automated keratometer), also known as auto refractor keratometer, is the instrument used in measurement of refractor error degree in the eye. This automated refractor is a computer-controlled machine used in the eye examination and offers optimal refractive error measurements. Furthermore, auto keratometers are used in assessing the patient condition in pre and pro refractive surgeries and have extended applications in ophthalmology. Myopia (nearsightedness) and hyperopia (farsightedness) are common vision problems and mainly occur due to refractive errors. Auto keratometer can perform spherical and cylindrical measurements in a range of -30 to +25D/±10D respectively. These provide cornea’s peripheral and central curvatures at various points and are widely used in determining astigmatism in the patient.

Key Drivers and Restraints of Global Auto Keratometer Market

  • Increase in incidence of myopia and other refractive errors, launch of ophthalmic instruments offering accurate readings, and technological advancements are major driving factors for the auto keratometer market. Furthermore, rise in awareness about astigmatism and its diagnosis is likely to be another driving factor for the auto keratometer market. Increase in number of ophthalmic clinics in the developing regions and diagnosis accuracy offered by auto keratometer are likely to drive the global market. Availability of various treatments such as lenses and Lasik surgery, are expected to lower the complications of astigmatism condition.
  • Manufacturers have integrated auto refractor in the products in order to improve efficiency which has enhanced accuracy and demand of the auto keratometers. Surge in number of patients suffering from post-cataract surgery and pre-existing astigmatism condition is another prevailing factor for the market growth globally. High cost of auto keratometers over manual keratometers is major restraining factor for the auto keratometer market.

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North America to Lead Global Auto Keratometer Market

  • In terms of region, the global Auto Keratometer Market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa
  • North America is projected to dominate the auto keratometer market during the forecast period, owing to technological advancements in development of automated keratometer, growing demand of diagnosis of refractory errors, prevalence of astigmatism condition, supportive health care expenditure, government initiatives, and creating awareness about astigmatism condition in the region. Presence of key players in developing automated keratometer is major boosting factor for growth of the market in the region. Moreover, surge in health care expenditure and advanced health care facilities are anticipated to fuel the growth of the auto keratometer market in the region. Europe is estimated to hold the second largest share of the global market followed by Asia pacific in the next few year. Growing demand and availability of automated keratometer, and increasing health care expenditure are major factors boosting the auto keratometer market in Europe.
  • Asia Pacific is a fastest growing region in the next few years, owing to the growing patient population suffering from astigmatism condition. According to the WHO, the prevalence of myopia is higher in younger adults among population of Asia. Prevalence of myopia is recorded higher in East Asia. Moreover, China, Japan, and Singapore had a total prevalence rate of myopia up to 50% in 2015. Comparatively, the prevalence of myopia estimated as per NCBI research was around 6.8% to 21.6% in 2016 globally.

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Key Manufacturers Operating in Global Auto Keratometer Market

The market of auto keratometer is consolidated and major share is captured by prominent few players. Major Key players involved in offering auto keratometers are:

  • NIDEK CO., LTD
  • Topcon Corporation
  • INNOVA Medical
  • Luneau Technology Group
  • Coburn Technologies, Inc.
  • Alcon
  • Essilor
  • Carl Zeiss AG
  • AMETEK Inc. and Reichert Inc.
  • SCHWIND eye-tech-solutions
...